Cramp-fasciculation syndrome can be characterized by acute onset of action induced muscle cramps without weakness or muscle atrophy. The neurological examination is normal except for fasciculation or myokymia. Electromyo graphy (EMG) shows
fasciculation
and muscle biopsy biopsy may show neurogenic abnormalities.
We describe a 65 years old woman who had muscle cramps and fasciculations in the hands and bilateral feet for 2 months. Laboratory studies including CBC, erythrocyte sedimentation rate, serum electrolytes, blood chemistries, creatine kinase,
serum
magnesium, serum electrolytes, blood chemistries, creatine kinase, serum magnesium, serum ionized calcium, thyroid function tests, parathyroid function tests, urinalysis were all normal. Motor and sensory nerve conduction studies were normal. EMG
study
showed fasciculation in the right abductor pollicis brevis muscle and the bilateral anterior tibialis muscles There were no showers of electrical potentials following the M-wave after repetitive median, ulnar, and peroneal nerve stimulation at
the
frequency of 1, 2, and 5-Hz.
She improved dramatically after vitamin E treatment.
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